Recently, a new study revealed previously unknown factors that contributed to the plaque growth and coagulating of arteries that cause heart disease. The research was led by scientists from Yale University and their insight is the foundation of a promising therapeutic way to stop and potentially invalidate plaque accumulation and the development of the disease. The research was published in the journal Nature Metabolism. The present treatments for atherosclerosis—plaque accumulation and hardened arteries—can slow but not develop the disease. The investigators believe that might be owing to constant inflammation in blood vessels.
To recognize the factors adding to this inflammation, the investigation team aimed at a group of proteins known as TGFß (transforming growth factor-beta) that controls a wide range of tissues and cells throughout the body. By the use of cultured human cells, the scientists found that TGFβ proteins activate inflammation in the endothelial cells in artery walls. By using single-cell RNA-seq analysis that measures the expression of each gene in single cells, they saw TGFβ stimulated inflammation in these cells in mouse prototypes. This finding from the research was notable as TGFβ proteins are known to reduce inflammation in other cells of the body.
Recently, Yale University was in the news as its research utilized rt fMRI (real-time functional magnetic resonance imaging) to cure Tourette syndrome. Characterized by vocalizations or recurring movements known as tics, Tourette syndrome is neurodevelopmental disarray that affects many adolescents. A study carried by researchers has trained adults with Tourette syndrome to manage their tics with an imaging technique that facilitates patients to examine the function of their own brain in real-time. This new study was published in the journal Biological Psychiatry. The study utilized rt-fMRI-NF (neurofeedback) that has a great perspective for treating neuropsychiatric disorders, as per to Michelle Hampson, Associate Professor at Yale University.